top of page

@ the Leukemia Atlases

overallschematic.png

Acute leukemias are extremely heterogeneous cancers of the blood and bone marrow. No known single attributes account for the diversity in response of adult and pediatric leukemia patients to chemotherapy. To address this clinical challenge and shed insight in the underlying biology of leukemia, we developed the Leukemia Proteome Atlases.

 

The atlases display in an interactive format, results from applying MetaGalaxy, a novel computational pipeline we designed, to proteomic data from leukemia patients' bone marrow biopsies. Patient outcomes were followed for 6 months to >>6 years. MetaGalaxy identifies functional protein networks and a global network signature that are indicative of clinical outcomes for patients with acute leukemias.

 

The atlases are divided into Adult and Pediatric, and the type of diagnosed leukemia (acute myeloid or acute lymphoblastic leukemia). Both global networks, the result of analyzing all protein functional groups simultaneous for all patients, and signatures from the individual protein functional groups are provided. 

Overall, the Leukemia Proteome Atlases provide quantitative, molecular hallmarks of leukemia; a broadly applicable computational approach to quantifying heterogeneity and similarity in molecular data; and a guide to new therapeutic targets for leukemias. 

Leadership

Team
Steven_Kornblau.jpg

Steven M. Kornblau, MD

AminaQutub-8370 - Copy (3)_edited.jpg

Amina Ann Qutub, PhD

TerzahHorton.jpg

Terzah Horton, MD, PhD

HistonePathway1.png

Eveline de Bont, MD, PhD

Team

Wendy Hu

Chenyue Wendy Hu, PhD

HistonePathway1.png

Yihu Qiu, PhD

FiekeHoff.jpg

Fieke Hoff

andrewligeralde_edited.png

Andrew Ligeralde

HistonePathway1.png

Suk Young Yoo, PhD

coombesweb.jpg

Kevin Coombes, PhD

HistonePathway1.png

Alexandria Raybon

Anneke.jpg

Anneke van Dijk

andreschultz_edited.png

André Schultz, PhD

HistonePathway1.png

David Noren, PhD

7H1A8088.jpg

Alex J. Bisberg

Quentin_Photo.jpg

Quentin Li

byronlong_edited_edited.png

Byron Long, PhD

jenniferdawkins1_edited_edited.png

Jennifer Dawkins

bottom of page